Proton Pump Inhibitors And The Prescribing Cascade

Research & Innovation

We studied drugs commonly prescribed for indigestion, peptic ulcer disease, and gastro-esophageal reflux disease (GERD) in three nursing homes. People who were taking many oral drugs and vitamins were more likely to be taking these drugs. Many drugs have anticholinergic properties, but too many anticholinergics can be problematic. There were major differences in the prescribing of anticholinergics in the three nursing homes. The Jewish Home had the lowest anticholinergic use. Anticholinergics can open up the lower esophagus, allowing gastric acids up into the esophagus.

This study found that residents with higher anticholinergic drug use were more likely to be taking a proton pump inhibitor drug.